Yeah, I see where you're coming from.
But when you break it down, there's "guilt," and there's "inappropriate guilt."
Most people will feel guilty about the stuff they're supposed to: lying, killing people, stealing. . . All of the big "ten commandment" stuff. No brainier shit.
Then there's the guilt that is imposed upon you by your: culture, family, religion, job. . . . and yourself. That's all pretty much inappropriate guilt. Bullshit nonsense heaped upon ourselves or others.
And yeah, the hate thing isn't far behind. Mostly when you hate and loathe your own existence.
I really would recommend a psychologist/psychotherapist. And if you've tried that already without success, try another.
My wife, who is still "in," has seen an absolute sea change in me since I started about 18 months ago.
Best of luck,
BOC